THE BEST SIDE OF METHADONE DRUG CLASS

[sixty one] Like numerous other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with distinctive potency. Dextromethadone, which is significantly less potent being an opioid, is more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone includes a lower affinity, w